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Phase 2 Trials: Obesity A landmark phase 2 trial, published in The New England Journal of Medicine on June 26, 2023, evaluated retatrutides efficacy and safety in 338 adults with obesity (BMI 30 kg/m or 2730 kg/m with weight-related conditions, excluding T2D)

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The notion for combining entero-pancreatic hormone-based therapies for obesity treatment is supported by the efficacy of bariatric surgery on WL, an intervention leading to increased postprandial levels of multiple entero-pancreatic hormones [31, 32]

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